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Science 8 July 1977:
Vol. 197. no. 4299, pp. 181 - 183
DOI: 10.1126/science.17917
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Articles

Science, Vol 197, Issue 4299, 181-183
Copyright © 1977 by American Association for the Advancement of Science

articles

Haloperidol: effect of long-term treatment on rat striatal dopamine synthesis and turnover

P Lerner, P Nose, EK Gordon, and W Lovenberg

The short- and long-term effects of neuroleptic drugs differ both clinically and biochemically. Short-term treatment with such a drug causes a kinetic activation of striatal tyrosine hydroxylase. Long-term treatment causes a prompt activation of the enzyme which is followed by a delayed, compensatory deactivation below control levels. Tolerance also develops to the stimulating effect of haloperidol on striatal dopamine turnover.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Increased Site-Specific Phosphorylation of Tyrosine Hydroxylase Accompanies Stimulation of Enzymatic Activity Induced by Cessation of Dopamine Neuronal Activity.
J. Y. Lew, A. Garcia-Espana, K. Y. Lee, K. D. Carr, M. Goldstein, J. W. Haycock, and E. Meller (1999)
Mol. Pharmacol. 55, 202-209
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Neuroleptic-induced decrease in plasma homovanillic acid and antipsychotic activity in schizophrenic patients.
D Pickar, R Labarca, M Linnoila, A Roy, D Hommer, D Everett, and S. Paul (1984)
Science 225, 954-957
   Abstract »    PDF »
Neurochemical Compensation After Nigrostriatal Bundle Injury in an Animal Model of Preclinical Parkinsonism.
M. J. Zigmond, A. L. Acheson, M. K. Stachowiak, and E. M. Strickerm (1984)
Arch Neurol 41, 856-861
   Abstract »    PDF »
Antipsychotic drug action in schizophrenic patients: effect on cortical dopamine metabolism after long-term treatment.
N. Bacopoulos, E. Spokes, E. Bird, and R. Roth (1979)
Science 205, 1405-1407
   Abstract »    PDF »
Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food.
R. Wise, J Spindler, H deWit, and G. Gerberg (1978)
Science 201, 262-264
   Abstract »    PDF »


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