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Science 1 July 1977:
Vol. 197. no. 4298, pp. 77 - 79
DOI: 10.1126/science.867053
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Articles

Science, Vol 197, Issue 4298, 77-79
Copyright © 1977 by American Association for the Advancement of Science

articles

Androgen concentration in motor neurons of cranial nerves and spinal cord

M Sar and WE Stumpf

After injection of [3H]dihydrotestosterone, a major testosterone metabolite, radioactivity is concentrated in nuclei of certain cells in the midbrain, pons, medulla oblongata, cerebellum, and spinal cord. While there is some overlap between androgen and estrogen target neuron distribution, certain motor neurons appear to be selectively labeled by androgen; in contrast, estrogen localization prevails in sensory neurons. These results may help to explain why male sexual behavior in some rodents is not fully activated with dihydrotestosterone alone but in addition requires estradiol, a testosterone metabolite.


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