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Science 1 July 1977:
Vol. 197. no. 4298, pp. 64 - 65
DOI: 10.1126/science.194311
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Articles

Science, Vol 197, Issue 4298, 64-65
Copyright © 1977 by American Association for the Advancement of Science

articles

Angiotensin converting enzyme: induction by steroids in rabbit alveolar macrophages in culture

J Friedland, C Setton, and E Silverstein

Dexamethasone and prednisone in physiologic range increased angiotensin converting enzyme 7- to 16-fold in comparison to control in 3 days at maximal stimulation (4 nM steroid) in rabbit alveolar macrophages in culture. The increase was inhibited by actinomycin D (0.1 microng/ml) and 1 micronM cycloheximide, suggesting that de novo transcription and enzyme synthesis are responsible for the increased enzyme activity. This result is evidence for a regulatory mechanism for angiotensin converting enzyme, which is important in blood pressure control.


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