Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 24 June 1977:
Vol. 196. no. 4297, pp. 1473 - 1475
DOI: 10.1126/science.867049
Prev | Table of Contents | Next

Articles

Science, Vol 196, Issue 4297, 1473-1475
Copyright © 1977 by American Association for the Advancement of Science

articles

Suppression of sympathetic nervous system during fasting

JB Young and L Landsberg

Two days of fasting in rats significantly reduces the turnover of norepinephrine in the heart. In contrast to the effects of ganglionic blockade in fed controls, similar blockade in fasted animals is without significant effect on [3H]-norepinephrine retention or endogenous norepinephrine in the heart. These data are consistent with suppression of centrally mediated sympathetic activity in the fasted state. The decrease in norepinephrine turnover during fasting is completely reversed by 1 day of refeeding.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Energetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connections.
K. M. Nautiyal, M. Dailey, N. Brito, M. N. d. A. Brito, R. B. Harris, T. J. Bartness, and H. J. Grill (2008)
Am J Physiol Regulatory Integrative Comp Physiol 295, R789-R798
   Abstract »    Full Text »    PDF »
Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality.
S. J. Swoap, C. Li, J. Wess, A. D. Parsons, T. D. Williams, and J. M. Overton (2008)
Am J Physiol Heart Circ Physiol 294, H1581-H1588
   Abstract »    Full Text »    PDF »
Direct Stimulation of Ghrelin Secretion by Sympathetic Nerves.
T. O. Mundinger, D. E. Cummings, and G. J. Taborsky Jr (2006)
Endocrinology 147, 2893-2901
   Abstract »    Full Text »    PDF »
Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats.
D. E. Mager, R. Wan, M. Brown, A. Cheng, P. Wareski, D. R. Abernethy, and M. P. Mattson (2006)
FASEB J 20, 631-637
   Abstract »    Full Text »    PDF »
Energy Expenditure and Body Composition of Chronically Maintained Decerebrate Rats in the Fed and Fasted Condition.
R. B. S. Harris, E. W. Kelso, W. P. Flatt, T. J. Bartness, and H. J. Grill (2006)
Endocrinology 147, 1365-1376
   Abstract »    Full Text »    PDF »
Learning Hunger: Conditioned Anticipatory Ghrelin Responses in Energy Homeostasis.
K. Teff (2006)
Endocrinology 147, 20-22
   Full Text »    PDF »
The Lack of {beta}-Adrenoceptors Results in Enhanced Insulin Sensitivity in Mice Exhibiting Increased Adiposity and Glucose Intolerance.
C. Asensio, M. Jimenez, F. Kuhne, F. Rohner-Jeanrenaud, and P. Muzzin (2005)
Diabetes 54, 3490-3495
   Abstract »    Full Text »    PDF »
Homeostatic responses to caloric restriction: influence of background metabolic rate.
S. A. Evans, A. D. Parsons, and J. M. Overton (2005)
J Appl Physiol 99, 1336-1342
   Abstract »    Full Text »    PDF »
Regional-dependent Increase of Sympathetic Innervation in Rat White Adipose Tissue during Prolonged Fasting.
A. Giordano, A. Frontini, I. Murano, C. Tonello, M. A. Marino, M. O. Carruba, E. Nisoli, and S. Cinti (2005)
J. Histochem. Cytochem. 53, 679-687
   Abstract »    Full Text »    PDF »
Sympathetic nervous system activity in rat thyroid: potential role in goitrogenesis.
J. B. Young, M. E. Burgi-Saville, U. Burgi, and L. Landsberg (2005)
Am J Physiol Endocrinol Metab 288, E861-E867
   Abstract »    Full Text »    PDF »
Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy.
T. O. Mundinger, Q. Mei, D. P. Figlewicz, A. Lernmark, and G. J. Taborsky Jr (2003)
Am J Physiol Endocrinol Metab 285, E1047-E1054
   Abstract »    Full Text »    PDF »
Effects of fasting on thermoregulatory processes and the daily oscillations in rats.
K. Nagashima, S. Nakai, K. Matsue, M. Konishi, M. Tanaka, and K. Kanosue (2003)
Am J Physiol Regulatory Integrative Comp Physiol 284, R1486-R1493
   Abstract »    Full Text »    PDF »
Role of Psychosocial and Nutritional Stress on Poor Pregnancy Outcome.
C. Hobel and J. Culhane (2003)
J. Nutr. 133, 1709S-1717
   Abstract »    Full Text »    PDF »
Seasonal Changes in Adiposity: the Roles of the Photoperiod, Melatonin and Other Hormones, and Sympathetic Nervous System.
T. J. Bartness, G. E. Demas, and C. K. Song (2002)
Experimental Biology and Medicine 227, 363-376
   Abstract »    Full Text »    PDF »
Fos expression in rat celiac ganglion: an index of the activation of postganglionic sympathetic nerves.
Q. Mei, T. O. Mundinger, D. Kung, D. G. Baskin, and G. J. Taborsky Jr. (2001)
Am J Physiol Endocrinol Metab 281, E655-E664
   Abstract »    Full Text »    PDF »
Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats.
J. M. Overton, T. D. Williams, J. B. Chambers, and M. E. Rashotte (2001)
Am J Physiol Regulatory Integrative Comp Physiol 280, R1007-R1015
   Abstract »    Full Text »    PDF »
Central Leptin Infusion Attenuates the Cardiovascular and Metabolic Effects of Fasting in Rats.
J. M. Overton, T. D. Williams, J. B. Chambers, and M. E. Rashotte (2001)
Hypertension 37, 663-669
   Abstract »    Full Text »    PDF »
Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function.
M. Rosenbaum, J. Hirsch, E. Murphy, and R. L Leibel (2000)
Am. J. Clinical Nutrition 71, 1421-1432
   Abstract »    Full Text »    PDF »
Overweight and Hypertension : A 2-Way Street?.
S. Julius, M. Valentini, and P. Palatini (2000)
Hypertension 35, 807-813
   Abstract »    Full Text »    PDF »
Defense of body weight against chronic caloric restriction in obesity-prone and -resistant rats.
B. E. Levin and A. A. Dunn-Meynell (2000)
Am J Physiol Regulatory Integrative Comp Physiol 278, R231-R237
   Abstract »    Full Text »    PDF »
Concurrent reductions in blood pressure and metabolic rate during fasting in the unrestrained SHR.
T. D. Williams, J. B. Chambers, O. L. May, R. P. Henderson, M. E. Rashotte, and J. M. Overton (2000)
Am J Physiol Regulatory Integrative Comp Physiol 278, R255-R262
   Abstract »    Full Text »    PDF »
Starvation: Early Signals, Sensors, and Sequelae.
M. F. Dallman, S. F. Akana, S. Bhatnagar, M. E. Bell, S. Choi, A. Chu, C. Horsley, N. Levin, O. Meijer, L. R. Soriano, et al. (1999)
Endocrinology 140, 4015-4023
   Abstract »    Full Text »
Effect of short-term fasting on lipid kinetics in lean and obese women.
J. F. Horowitz, S. W. Coppack, D. Paramore, P. E. Cryer, G. Zhao, and S. Klein (1999)
Am J Physiol Endocrinol Metab 276, E278-E284
   Abstract »    Full Text »    PDF »
Insulin as a Vascular and Sympathoexcitatory Hormone : Implications for Blood Pressure Regulation, Insulin Sensitivity, and Cardiovascular Morbidity.
U. Scherrer and C. Sartori (1997)
Circulation 96, 4104-4113
   Abstract »    Full Text »
Hypertension and Associated Metabolic Abnormalities -- The Role of Insulin Resistance and the Sympathoadrenal System.
G. M. Reaven, H. Lithell, and L. Landsberg (1996)
N. Engl. J. Med. 334, 374-382
   Full Text »    PDF »
Pressor Effects of Portal Venous Oleate Infusion : A Proposed Mechanism for Obesity Hypertension.
R. J. Grekin, A. P. Vollmer, and R. S. Sider (1995)
Hypertension 26, 193-198
   Abstract »    Full Text »
Reduced Resting Metabolic Rate in Patients With Bulimia Nervosa.
E. Obarzanek, M. D. Lesem, D. S. Goldstein, and D. C. Jimerson (1991)
Arch Gen Psychiatry 48, 456-462
   Abstract »    PDF »
Hypotensive effect of fasting: possible involvement of the sympathetic nervous system and endogenous opiates.
D Einhorn, J. Young, and L Landberg (1982)
Science 217, 727-729
   Abstract »    PDF »
Cardiovascular and Respiratory Pathophysiological Alterations.
E. Reisin and E. D. Frohlich (1981)
Arch Intern Med 141, 431-434
   Abstract »    PDF »
Weight Reduction: Renal Mineral and Hormonal Excretion During Semistarvation in Obese Patients.
J. C. M. Chan and F. C. Bartter (1981)
JAMA 245, 371-373
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)