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Science 24 June 1977:
Vol. 196. no. 4297, pp. 1472 - 1473
DOI: 10.1126/science.867048
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Articles

Science, Vol 196, Issue 4297, 1472-1473
Copyright © 1977 by American Association for the Advancement of Science

articles

Cannabinoids inhibit testosterone secretion by mouse testes in vitro

S Dalterio, A Bartke, and S Burstein

Addition of delta-9-tetrahydrocannabinol or cannabinol to an incubation medium containing decapsulated mouse testes caused a significant reduction in the accumulation of testosterone in the medium. This result suggests that the reported effects of cannabis on male sexual and reproductive function may result from direct inhibition of testicular steroidogenesis by both psychoactive and nonpsychoactive constituents of marihuana.


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