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Science 24 June 1977:
Vol. 196. no. 4297, pp. 1469 - 1470
DOI: 10.1126/science.867046
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Articles

Science, Vol 196, Issue 4297, 1469-1470
Copyright © 1977 by American Association for the Advancement of Science

articles

Somatostatin: electron microscope immunohistochemical localization in secretory neurons of rat hypothalamus

G Pelletier, D Dube, and R Puviani

Somatostatin, the hypothalamic hormone which inhibits the secretion of growth hormone by the pituitary, has been localized in the rat hypothalamus by using electron microscope immunohistochemistry. Somatostatin occurs in secretory granules (80 to 110 nm in diameter) of a few neurons located in the hypothalamic periventricular nucleus. These observations establish the identity of neurosecretory neurons involved in the regulation of adenohypophyseal secretion.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)