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Science 24 June 1977:
Vol. 196. no. 4297, pp. 1456 - 1458
DOI: 10.1126/science.867042
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Articles

Science, Vol 196, Issue 4297, 1456-1458
Copyright © 1977 by American Association for the Advancement of Science

articles

Tumor antigen and human chorionic gonadotropin in CaSki cells: a new epidermoid cervical cancer cell line

RA Pattillo, RO Hussa, MT Story, AC Ruckert, MR Shalaby, and RF Mattingly

Epidermoid cervical carcinoma cells (CaSki line) have been established in continuous culture. When leukocytes from cervical cancer patients were incubated with CaSki culture fluid concentrates, inhibition of leukocyte migration was observed in more than 70 percent of the patients tested. By contrast, significantly less inhibition was observed with normal donor leukocytes or leukocytes from patients with other types of cancer. These results were consistent with the expression of tumor-associated antigen by CaSki cells. Analysis of the serum from the donor of the cell line at the time of tumor biopsy, and of CaSki culture fluids, demonstrated the presence of the beta subunit of human chorionic gonadotropin.


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