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Science 17 June 1977:
Vol. 196. no. 4296, pp. 1345 - 1347
DOI: 10.1126/science.559349
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Articles

Science, Vol 196, Issue 4296, 1345-1347
Copyright © 1977 by American Association for the Advancement of Science

articles

Lens cataract formation and reversible alteration in crystallin synthesis in cultured lenses

J Piatigorsky and T Shinohara

Embryonic chick lenses developed cortical cataracts and altered their pattern of delta-crystallin synthesis within 3 hours, if cultured without their vitreous body or traumatized with their vitreous body attached. delta-Crystallin reverted to the normal pattern by 24 hours in the cataractous lenses. Thus, biochemical differences that are only observable during the initial stages of cataractogenesis can exist between opaque and normal lenses.


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