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Science 17 June 1977:
Vol. 196. no. 4296, pp. 1336 - 1339
DOI: 10.1126/science.194310
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Articles

Science, Vol 196, Issue 4296, 1336-1339
Copyright © 1977 by American Association for the Advancement of Science

articles

Feline oncornavirus-associated cell membrane antigen: expression in transformed nonproducer mink cells

AH Sliski, M Essex, C Meyer, and G Todaro

The feline oncornavirus-associated cell membrane antigen (FOCMA) is a target for naturally occurring immunity that protects the cat against development of fibrosarcoma and leukemia. Feline sarcoma virus-transformed "nonproducer" mink cells express high levels of FOCMA, but not the major viral structural proteins. Transformation of the same cells by murine sarcoma virus, or infection with feline leukemia virus, which is nontransforming for epithelial or fibroblastic cells, did not induce FOCMA. Thus, FOCMA expression in mind lung cells is specifically associated with transformation by feline sarcoma virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Monoclonal Antibodies: Detection of Transformation-related Antigens.
S. S. VedBrat, U. Hammerling, W. D. Hardy Jr., E. Borenfreund, and W. Prensky (1980)
Cold Spring Harb Symp Quant Biol 44, 715-720
   Abstract »    PDF »
Isolation and Characterization of Proteins Carrying the Feline Oncornavirus-associated Cell-membrane Antigen.
H. W. Snyder Jr., K. J. Phillips, W. D. Hardy Jr., E. E. Zuckerman, M. Essex, A. H. Sliski, and J. Rhim (1980)
Cold Spring Harb Symp Quant Biol 44, 787-799
   Abstract »    PDF »


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