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Science 10 June 1977:
Vol. 196. no. 4295, pp. 1215 - 1216
DOI: 10.1126/science.323976
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Articles

Science, Vol 196, Issue 4295, 1215-1216
Copyright © 1977 by American Association for the Advancement of Science

articles

Hemoglobin ontogenesis: test of the gene excision hypothesis

T Papayannopoulou, PE Nute, G Stamatoyannopoulos, and TC McGuire

The gene excision hypothesis of hemoglobin ontogenesis was tested in persons with HbSC disease, with the use of monospecific fluorescent antibodies for the identification of hemoglobins S, C, and F in individual erythrocytes. The results are incompatible with the prediction that only one gamma- or beta-globin gene may be active in any single chromosome and provide further evidence for incomplete repression of gamma-globin genes lying cis to active beta-globin genes.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)