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Science 3 June 1977:
Vol. 196. no. 4294, pp. 1114 - 1115
DOI: 10.1126/science.404711
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Articles

Science, Vol 196, Issue 4294, 1114-1115
Copyright © 1977 by American Association for the Advancement of Science

articles

Genetic rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster

MB Hughes and JC Lucchesi

While a null activity mutant allele of the structural gene for 6-phosphogluconate dehydrogenase in Drosophila melanogaster is lethal, a similar mutation for glucose-6-phosphate dehydrogenase is not. Double mutant combinations lacking both enzyme activities, obtained either by recombination or by mutagen treatment of a chromosome bearing the lethal allele, result in a restoration of viability. The indispensability of the pentose phosphate shunt in Drosophila appears to depend upon the specific position of the block within the pathway.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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K. M. Mayer and F. H. Arnold (2002)
J Biomol Screen 7, 135-140
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