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Science 3 June 1977:
Vol. 196. no. 4294, pp. 1109 - 1111
DOI: 10.1126/science.16343
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Articles

Science, Vol 196, Issue 4294, 1109-1111
Copyright © 1977 by American Association for the Advancement of Science

articles

Direct resorption of bone by human monocytes

CR Mundy, AJ Altman, MD Gondek, and JG Bandelin

Cultured human peripheral blood monocytes stimulate the release of bone mineral and matrix from killed long bones of fetal rats. These effects were inhibited by cortisol but were not altered by hormones that normally stimulate osteoclastic bone resorption. There was no evidence of morphologic differentiation of the monocytes into osteoclasts during bone resorption.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)