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Science 20 May 1977:
Vol. 196. no. 4292, pp. 892 - 894
DOI: 10.1126/science.870966
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Articles

Science, Vol 196, Issue 4292, 892-894
Copyright © 1977 by American Association for the Advancement of Science

articles

Mouse chromosome translocations: visualization and analysis by electron microscopy of the synaptonemal complex

MJ Moses, LB Russel, and NL Cacheiro

Pachytene chromosomes of mice heterozygous for known translocations are clearly depicted by configurations of the synaptonemal complexes in spread (whole mount) preparations. In one autosomal and two X-autosome translocations analyzed, breakpoints are identifiable; localization by measurement agrees with mitotic data and shows the translocations to be reciprocal. Synapsis with the Y is inhibited in one translocation in which the breakpoint is the pairing region of the X.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)