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Science 20 May 1977:
Vol. 196. no. 4292, pp. 883 - 885
DOI: 10.1126/science.404708
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Articles

Science, Vol 196, Issue 4292, 883-885
Copyright © 1977 by American Association for the Advancement of Science

articles

Covalent labeling of the tetrodotoxin receptor in excitable membranes

RJ Guillory, MD Rayner, and JS D'Arrigo

A photoaffinity labeling technique is described by which a tetrodotoxin analog is covalently bound to receptor sites associated with the sodium pores of excitable membranes. The biological activity of the toxin analog is retained after the covalent binding reaction.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)