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Science 6 May 1977:
Vol. 196. no. 4290, pp. 684 - 685
DOI: 10.1126/science.193186
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Articles

Science, Vol 196, Issue 4290, 684-685
Copyright © 1977 by American Association for the Advancement of Science

articles

Drug tolerance in biomembranes: a spin label study of the effects of ethanol

JH Chin and DB Goldstein

Ethanol in vitro increased the fluidity of spin-labeled membranes from normal mice. Membranes from mice that had been subjected to long-term ethanol treatment were relatively resistant to this fluidizing effect. The data suggest that the membranes themselves had adapted to the drug, a novel form of drug tolerance.


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Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure.
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Bone Disease in Alcohol Abuse.
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Ethanol modulation of opiate receptors in cultured neural cells.
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