Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 May 1977:
Vol. 196. no. 4290, pp. 671 - 674
DOI: 10.1126/science.854742
Prev | Table of Contents | Next

Articles

Science, Vol 196, Issue 4290, 671-674
Copyright © 1977 by American Association for the Advancement of Science

articles

Virus-induced behavioral alteration of mice

J Hotchin and R Seegal

Neonatal mice were inoculated intracerebrally with lymphocytic choriomeningitis virus (LCM). These mice developed long-term persistent tolerant infections and when tested at 3.5 to 6.0 months of age they showed significant increases in behavioral latency when subjected to open-field tests, and significant decreases in the current level required to elicit to startle response and in locomotor activity in a running wheel. Comparable results were obtained with mice in which persistent infection was induced at 8 weeks of age and which were tested at 3.5 to 6.0 months of age. It was concluded that mice infected with LCM at birth or as adults exhibited long-lasting behavioral abnormalities.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Persistent Viral Infection Elevates Central Nervous System MHC Class I through Chronic Production of Interferons.
P. Truong, S. Heydari, L. Garidou, and D. B. McGavern (2009)
J. Immunol. 183, 3895-3905
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)