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Science 29 April 1977:
Vol. 196. no. 4289, pp. 542 - 545
DOI: 10.1126/science.850797
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Articles

Science, Vol 196, Issue 4289, 542-545
Copyright © 1977 by American Association for the Advancement of Science

articles

Partial denervation affects both denervated and innervated fibers in the mammalian skeletal muscle

A Cangiano and L Lutzemberger

Partial denervation of the rat extensor digitorum longus muscle was performed by sectioning only one of the sciatic nerve roots. Measurements of spike resistance to tetrodotoxin in individual muscle fibers revealed denervation changes not only in the denervated fibers but also in the adjacent innervated ones. The results support the concept that products of nerve degeneration play a role in the origin of muscle changes induced by denervation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Expression of small-conductance calcium-activated potassium channels (SK3) in skeletal muscle: regulation by muscle activity.
M. Favero, D.-J. Jiang, C. Chiamulera, A. Cangiano, and G. F. Fumagalli (2008)
J. Physiol. 586, 4763-4774
   Abstract »    Full Text »    PDF »
Degenerating nerve fiber products do not alter physiological properties of adjacent innervated skeletal muscle fibers.
T. Tiedt, E. Albuquerque, and L Guth (1977)
Science 198, 839-841
   Abstract »    PDF »


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