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Science 29 April 1977:
Vol. 196. no. 4289, pp. 540 - 542
DOI: 10.1126/science.850796
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Articles

Science, Vol 196, Issue 4289, 540-542
Copyright © 1977 by American Association for the Advancement of Science

articles

Denervated skeletal muscle fibers develop discrete patches of high acetylcholine receptor density

PK Ko, MJ Anderson, and MW Cohen

Denervated skeletal muscle fibers of mice develop discrete patches of high acetylcholine receptor density. The patches vary in size from less than 1 micrometer up to 30 micrometers, depending on the muscle and the period of denervation. Within the patches the acetylcholine receptor density is some 20 times greater than elsewhere along the muscle fiber and probably approaches that in the subsynaptic membrane.


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