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Science 22 April 1977:
Vol. 196. no. 4288, pp. 444 - 447
DOI: 10.1126/science.850788
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Articles

Science, Vol 196, Issue 4288, 444-447
Copyright © 1977 by American Association for the Advancement of Science

articles

Major innervation of newborn rat cortex by monoaminergic neurons

JT Coyle and ME Molliver

A major monoaminergic innervation in infant rat neocortex, predominantly in layer IV, has been demonstrated by ultrastructural and biochemical studies after the administration of exogenous catecholamine precursors and congeners. One-third of all cortical synapses have an uptake-storage mechanism for catecholamines. In newborn cortex, the storage capacity for catecholamines is tenfold greater than the endogenous levels, and the uptake-storage mechanism matures earlier than the ability to synthesize neurotransmitter.


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Noradrenergic innervation of cerebral cortex: widespread effects of local cortical lesions.
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