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Science 22 April 1977:
Vol. 196. no. 4288, pp. 390 - 405
DOI: 10.1126/science.850784
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Articles

Science, Vol 196, Issue 4288, 390-405
Copyright © 1977 by American Association for the Advancement of Science

articles

The status of the gene map of the human chromosomes

VA McKusick and FH Ruddle

In man, the specific chromosome that carries each of about 210 gene loci is known. These loci include at least one assigned to each chromosome (including the Y), about 110 assigned to specific autosomes, and about 100 to the X chromosome. For many loci, information on regional chromosomal localization is also available. The information comes mainly from studies in families and somatic cell hybrids, as well as an intgratsight of results from the two methods. Knowledge of the chromosome map gives insight into evolution, chromosomal organization in relation to genetic control mechanisms, and the pathogenesis of neoplasms and malformations. Furthermore, it is useful in prenatal or premorbid diagnosis of hereditary diseases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Anatomy of the Human Genome: A Neo-Vesalian Basis for Medicine in the 21st Century.
V. A. McKusick (2001)
JAMA 286, 2289-2295
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Molecular Analysis of Human X-linked Diseases.
K.E. Davies, S.P. Ball, H.R. Dorkins, S.M. Forrest, S.J. Kenwrick, A.W. King, I.J.D. Lavenir, S.A. McGlade, M.N. Patterson, T.J. Smith, et al. (1986)
Cold Spring Harb Symp Quant Biol 51, 337-343
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Genetic mapping in mammals: chromosome map of domestic cat.
S. O'Brien and W. Nash (1982)
Science 216, 257-265
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Human cell hybrids: analysis of transformation and tumorigenicity.
E. Stanbridge, C. Der, C. Doersen, R. Nishimi, D. Peehl, B. Weissman, and J. Wilkinson (1982)
Science 215, 252-259
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Hereditary Ataxia and the Sixth Chromosome.
A. H. Koeppen, H. W. Goedde, C. Hiller, L. Hirth, and H.-G. Benkmann (1981)
Arch Neurol 38, 158-164
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Variability in the Y Chromosome and Variability of Human Behavior.
E. Dorus (1980)
Arch Gen Psychiatry 37, 587-594
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Evolution of primate chromosomes.
D. Miller (1977)
Science 198, 1116-1124
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