Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 April 1977:
Vol. 196. no. 4287, pp. 326 - 328
DOI: 10.1126/science.847477
Prev | Table of Contents | Next

Articles

Science, Vol 196, Issue 4287, 326-328
Copyright © 1977 by American Association for the Advancement of Science

articles

Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain

DR Burt, I Creese, and SH Snyder

Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal dopamine receptor binding assayed with [3H]haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
"Breakthrough" Dopamine Supersensitivity during Ongoing Antipsychotic Treatment Leads to Treatment Failure over Time.
A.-N. Samaha, P. Seeman, J. Stewart, H. Rajabi, and S. Kapur (2007)
J. Neurosci. 27, 2979-2986
   Abstract »    Full Text »    PDF »
Dopamine Modulates Release from Corticostriatal Terminals.
N. S. Bamford, S. Robinson, R. D. Palmiter, J. A. Joyce, C. Moore, and C. K. Meshul (2004)
J. Neurosci. 24, 9541-9552
   Abstract »    Full Text »    PDF »
Supersensitivity of Human Metabotropic Glutamate 1a Receptor Signaling in L929sA Cells.
H. Lavreysen, E. Le Poul, P. Van Gompel, L. Dillen, J. E. Leysen, and A. S. J. Lesage (2002)
Mol. Pharmacol. 61, 1244-1254
   Abstract »    Full Text »    PDF »
Differential Regulation of Dopamine D2 and D3 Receptors by Chronic Drug Treatments.
G. D. Stanwood, I. Lucki, and P. McGonigle (2000)
J. Pharmacol. Exp. Ther. 295, 1232-1240
   Abstract »    Full Text »
Behavioral Evidence of Depolarization Block of Dopamine Neurons after Chronic Treatment with Haloperidol and Clozapine.
S. M. Boye and P.-P. Rompre (2000)
J. Neurosci. 20, 1229-1239
   Abstract »    Full Text »    PDF »
L-Type Ca2+ Channels Are Essential for Glutamate-Mediated CREB Phosphorylation and c-fos Gene Expression in Striatal Neurons.
A. Rajadhyaksha, A. Barczak, W. Macias, J.-C. Leveque, S. E. Lewis, and C. Konradi (1999)
J. Neurosci. 19, 6348-6359
   Abstract »    Full Text »    PDF »
Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies.
M. Laruelle and A. Abi-Dargham (1999)
J Psychopharmacol 13, 358-371
   Abstract »    PDF »
Clinical and Theoretical Implications of 5-HT2 and D2 Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia.
S. Kapur, R. B. Zipursky, and G. Remington (1999)
Am J Psychiatry 156, 286-293
   Abstract »    Full Text »
Delayed Normalization of Central D2 Dopamine Receptor Availability After Discontinuation of Haloperidol Decanoate: Preliminary Findings.
S. Nyberg, L. Farde, and C. Halldin (1997)
Arch Gen Psychiatry 54, 953-958
   Abstract »    PDF »
Dopamine Receptor Subtypes: Differential Regulation after 8 Months Treatment with Antipsychotic Drugs.
W. J. Florijn, F. I. Tarazi, and I. Creese (1997)
J. Pharmacol. Exp. Ther. 280, 561-569
   Abstract »    Full Text »
Cell-Cell Signaling in Early Cortical Development.
A. R. Kriegstein (1995)
Neuroscientist 1, 268-276
   Abstract »    PDF »
Striatal D2 Dopamine Receptor Characteristics in Neuroleptic-Naive Schizophrenic Patients Studied With Positron Emission Tomography.
J. Hietala, E. Syvalahti, K. Vuorio, K. Nagren, P. Lehikoinen, U. Ruotsalainen, V. RakkOlainen, V. Lehtinen, and U. Wegelius (1994)
Arch Gen Psychiatry 51, 116-123
   Abstract »    PDF »
Positron Emission Tomographic Analysis of Central D1 and D2 Dopamine Receptor Occupancy in Patients Treated With Classical Neuroleptics and Clozapine: Relation to Extrapyramidal Side Effects.
L. Farde, A.-L. Nordstrom, F.-A. Wiesel, S. Pauli, C. Halldin, and G. Sedvall (1992)
Arch Gen Psychiatry 49, 538-544
   Abstract »    PDF »
Seasonal Independence of Low Prolactin Concentration and High Spontaneous Eye Blink Rates in Unipolar and Bipolar II Seasonal Affective Disorder.
R. A. Depue, P. Arbisi, S. Krauss, W. G. Iacono, A. Leon, R. Muir, and J. Allen (1990)
Arch Gen Psychiatry 47, 356-364
   Abstract »    PDF »
D2 Dopamine Receptors in Neuroleptic-Naive Schizophrenic Patients: A Positron Emission Tomography Study With [11C]Raclopride.
L. Farde, F.-A. Wiesel, S. Stone-Elander, C. Halldin, A.-L. Nordstrom, H. Hall, and G. Sedvall (1990)
Arch Gen Psychiatry 47, 213-219
   Abstract »    PDF »
Central D2-Dopamine Receptor Occupancy in Schizophrenic Patients Treated With Antipsychotic Drugs.
L. Farde, F.-A. Wiesel, C. Halldin, and G. Sedvall (1988)
Arch Gen Psychiatry 45, 71-76
   Abstract »    PDF »
Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.
D. Wong, H. Wagner Jr, L. Tune, R. Dannals, G. Pearlson, J. Links, C. Tamminga, E. Broussolle, H. Ravert, A. Wilson, et al. (1986)
Science 234, 1558-1563
   Abstract »    PDF »
Penrsistent Tardive Dyskinesia in Bipolar Patients.
S. Mukherjee, A. M. Rosen, G. Caracci, and S. Shukla (1986)
Arch Gen Psychiatry 43, 342-346
   Abstract »    PDF »
Schneider's First-Rank Symptoms of Schizophrenia: An Association With Increased Growth Hormone Response to Apomorphine.
L. J. Whalley, J. E. Christie, S. Brown, and G. W. Arbuthnott (1984)
Arch Gen Psychiatry 41, 1040-1043
   Abstract »    PDF »
Drug and neurotransmitter receptors in the brain.
S. Snyder (1984)
Science 224, 22-31
   Abstract »    PDF »
Imaging dopamine receptors in the human brain by positron tomography.
H. Wagner Jr, H. Burns, R. Dannals, D. Wong, B Langstrom, T Duelfer, J. Frost, H. Ravert, J. Links, S. Rosenbloom, et al. (1983)
Science 221, 1264-1266
   Abstract »    PDF »
Coupling of dopamine D1 recognition sites with adenylate cyclase in nuclei accumbens and caudatus of schizophrenics.
M Memo, J. Kleinman, and I Hanbauer (1983)
Science 221, 1304-1307
   Abstract »    PDF »
Spontaneous orofacial dyskinesia and dopaminergic function in rats after 6 months of neuroleptic treatment.
J. Waddington, A. Cross, S. Gamble, and R. Bourne (1983)
Science 220, 530-532
   Abstract »    PDF »
Increased Brain Dopamine and Dopamine Receptors in Schizophrenia.
A. V. P. Mackay, L. L. Iversen, M. Rossor, E. Spokes, E. Bird, A. Arregui, I. Creese, and S. H. Snyder (1982)
Arch Gen Psychiatry 39, 991-997
   Abstract »    PDF »
Cerebral Glucography With Positron Tomography: Use in Normal Subjects and in Patients With Schizophrenia.
M. S. Buchsbaum, D. H. Ingvar, R. Kessler, R. N. Waters, J. Cappelletti, D. P. van Kammen, A. C. King, J. L. Johnson, R. G. Manning, R. W. Flynn, et al. (1982)
Arch Gen Psychiatry 39, 251-259
   Abstract »    PDF »
Neuroleptic drug-induced dopamine receptor supersensitivity: antagonism by L-prolyl-L-leucyl-glycinamide.
S Chiu, C. Paulose, and R. Mishra (1981)
Science 214, 1261-1262
   Abstract »    PDF »
Clonidine Ameliorates Gilles de la Tourette Syndrome.
D. J. Cohen, J. Detlor, J. G. Young, and B. A. Shaywitz (1980)
Arch Gen Psychiatry 37, 1350-1357
   Abstract »    PDF »
Lithium reduces the number of acetylcholine receptors in skeletal muscle.
A Pestronk and D. Drachman (1980)
Science 210, 342-343
   Abstract »    PDF »
Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.
S. Peroutka and S. Snyder (1980)
Science 210, 88-90
   Abstract »    PDF »
Prostaglandins, Platelets, and Schizophrenia.
J. Rotrosen, A. D. Miller, D. Mandio, L. J. Traficante, and S. Gershon (1980)
Arch Gen Psychiatry 37, 1047-1054
   Abstract »    PDF »
Bromocriptine and Buccolinguofacial Dyskinesias in Patients With Senile Dementia: A Quantitative Study.
P. J. Delwaide and A. Hurlet (1980)
Arch Neurol 37, 441-443
   Abstract »    PDF »
Lack of Behavioral Supersensitivity to d-Amphetamine After Pimozide Withdrawal: A Trial With Schizophrenic Patients.
D. P. van Kammen, J. P. Docherty, S. R. Marder, S. C. Schulz, and W. E. Bunney Jr (1980)
Arch Gen Psychiatry 37, 287-290
   Abstract »    PDF »
Dopamine auto- and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists.
L. Skirboll, A. Grace, and B. Bunney (1979)
Science 206, 80-82
   Abstract »    PDF »
Mode of Action of Lithium: Some Biological Considerations.
W. E. Bunney Jr, A. Pert, J. Rosenblatt, C. B. Pert, and D. Gallaper (1979)
Arch Gen Psychiatry 36, 898-901
   Abstract »    PDF »
beta1- and beta2-Adrenergic receptors in rat cerebral cortex are independently regulated.
K. Minneman, M. Dibner, B. Wolfe, and P. Molinoff (1979)
Science 204, 866-868
   Abstract »    PDF »
Rapid changes in brain benzodiazepine receptors after experimental seizures.
S. Paul and P Skolnick (1978)
Science 202, 892-894
   Abstract »    PDF »
Long-term treatment with lithium prevents the development of dopamine receptor supersensitivity.
A Pert, J. Rosenblatt, C Sivit, C. Pert, and W. Bunney Jr (1978)
Science 201, 171-173
   Abstract »    PDF »
Modification of Tardive Dyskinesia and Spasmodic Torticollis by Apomorphine: Possible Role of Dopamine Autoreceptors.
E. S. Tolosa (1978)
Arch Neurol 35, 459-462
   Abstract »    PDF »
Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity.
I Creese, D. Burt, and S. Snyder (1977)
Science 197, 596-598
   Abstract »    PDF »
cAMP-dependent Protein Kinase Induces cAMP-response Element-binding Protein Phosphorylation via an Intracellular Calcium Release/ERK-dependent Pathway in Striatal Neurons.
P. Zanassi, M. Paolillo, A. Feliciello, E. V. Avvedimento, V. Gallo, and S. Schinelli (2001)
J. Biol. Chem. 276, 11487-11495
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)