Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
The Wellcome Trust

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 April 1977:
Vol. 196. no. 4285, pp. 67 - 70
DOI: 10.1126/science.841340
Prev | Table of Contents | Next

Articles

Science, Vol 196, Issue 4285, 67-70
Copyright © 1977 by American Association for the Advancement of Science

articles

Babesia rodhaini: requirement of complement for penetration of human erythrocytes

WE Chapman and PA Ward

A system has been developed in vitro in which human red cells, in the presence of fresh human (or rat) serum, are parasitized by the hemosporidian protozoan Babesia rodhaini. The ability of B. rodhaini to penetrate red cells depends on factors of the alternative complement pathway (properdin and factor B) as well as ionic magnesium and the third (C3) and the fifth (C5) components of complement. These data indicate a novel mechanism by which a parasite is able to utilize the complement system. The data are in accord with and further amplify earlier observations that demonstrated a requirement for complement in the development of babesial infection in rats.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Babesiosis.
M. J. Homer, I. Aguilar-Delfin, S. R. Telford III, P. J. Krause, and D. H. Persing (2000)
Clin. Microbiol. Rev. 13, 451-469
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)