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Science 1 April 1977:
Vol. 196. no. 4285, pp. 56 - 59
DOI: 10.1126/science.300174
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Articles

Science, Vol 196, Issue 4285, 56-59
Copyright © 1977 by American Association for the Advancement of Science

articles

Prevention of autoimmunity in experimental lupus erythematosus by soluble immune response suppressor

RS Krakauer, W Strober, DL Rippeon, and TA Waldmann

Young NZB/W mice, treated with injections of soluble immune response suppressor (SIRS)(supernatant from mouse spleen cells exposed to concanavalin A), showed decreased immunoglobulin levels, less antibody to cell nuclei, less proteinuria, and less renal pathology as compared with NZB/W mice receiving a control preparation. Thus, SIRS administration beginning at an early age appears to be an effective therapy of the autoimmune disease in NZB/W mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Disorders of Suppressor Immunoregulatory Cells in the Pathogenesis of Immunodeficiency and Autoimmunity.
T. A. WALDMANN, R. M. BLAESE, S. BRODER, and R. S. KRAKAUER (1978)
Ann Intern Med 88, 226-238
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