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Science 25 March 1977:
Vol. 195. no. 4284, pp. 1356 - 1358
DOI: 10.1126/science.14400
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Articles

Science, Vol 195, Issue 4284, 1356-1358
Copyright © 1977 by American Association for the Advancement of Science

articles

Glutamine synthetase: glial localization in brain

A Martinez-Hernandez, KP Bell, and MD Norenberg

Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, gamma-aminobutyric acid, and ammonia metabolism in brain.


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