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Science 25 March 1977:
Vol. 195. no. 4284, pp. 1293 - 1300
DOI: 10.1126/science.320663
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Articles

Science, Vol 195, Issue 4284, 1293-1300
Copyright © 1977 by American Association for the Advancement of Science

articles

Functional specificity of thymus- dependent lymphocytes

WE Paul and B Benacerraf

Thymus-dependent lymphocytes display a restricted range of specificity when compared to thymus-independent (B) lymphocytes. They react particularly to thymus-dependent protein and cell surface antigens and to products of genes encoded in the MHC. In addition, T lymphocytes have important functions in regulating the immune response and in discriminating of self from nonself. Recent work indicates that individual T lymphocytes possess receptors that interact with both thymus-dependent antigens and MHC gene products, either independently or as associated structures. We attempt to relate this complex specificity pattern to the regulatory and surveillance functions of T lymphocytes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes.
S. Meuer, D. Cooper, J. Hodgdon, R. Hussey, K. Fitzgerald, S. Schlossman, and E. Reinherz (1983)
Science 222, 1239-1242
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Role of MHC gene products in immune regulation.
B Benacerraf (1981)
Science 212, 1229-1238
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