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Science 11 March 1977:
Vol. 195. no. 4282, pp. 982 - 990
DOI: 10.1126/science.14399
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Articles

Science, Vol 195, Issue 4282, 982-990
Copyright © 1977 by American Association for the Advancement of Science

articles

Possible cyclic nucleotide regulation of calcium mediating myocardial contraction

A Schwartz, ML Endman, EG Ezrailson, DC Lehotay, and G Leyey

An inhibitor of adenylate and guanylate cyclases was tested on strips of left atria from rabbits. Effects of catecholamines (cardiotonic) and of acetylcholine (cardiodepressive) were blocked, and positive force-frequency was converted to negative. Ouabain produced only contracture without positive inotropy. The cardiotonic effect of increased calcium remained. Data suggest that cyclic nucleotides modulate calcium associated with these stimuli.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phospholamban-to-SERCA2 ratio controls the force-frequency relationship.
M. Meyer, W. F. Bluhm, H. He, S. R. Post, F. J. Giordano, W. Y. W. Lew, and W. H. Dillmann (1999)
Am J Physiol Heart Circ Physiol 276, H779-H785
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