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Science 4 March 1977:
Vol. 195. no. 4281, pp. 892 - 894
DOI: 10.1126/science.841314
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Articles

Science, Vol 195, Issue 4281, 892-894
Copyright © 1977 by American Association for the Advancement of Science

articles

Pathogenic mycoplasmas: cultivation and vertebrate pathogenicity of a new spiroplasma

JG Tully, RF Whitcomb, HF Clark, and DL Williamson

A spiroplasma recovered from allantoic fluids of chick embryos infected with the tick-derived suckling mouse cataract agent was grown in continuous passage on a new artificial culture medium. The cultured organisms induced typical ocular and other disease symptoms in susceptible animals, and were reisolated from involved host tissues. Although spiroplasmas have been previously recognized as plant and insect pathogens, this is the first spiroplasma shown to multiply at 37 degrees C and to be pathogenic for vertebrates.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Spiroplasma spp. from transmissible spongiform encephalopathy brains or ticks induce spongiform encephalopathy in ruminants.
F. O. Bastian, D. E. Sanders, W. A. Forbes, S. D. Hagius, J. V. Walker, W. G. Henk, F. M. Enright, and P. H. Elzer (2007)
J. Med. Microbiol. 56, 1235-1242
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Mycoplasma fermentans and TNF-beta interact to amplify immune-modulating cytokines in human lung fibroblasts.
J. P. Fabisiak, F. Gao, R. G. Thomson, R. M. Strieter, S. C. Watkins, and J. H. Dauber (2006)
Am J Physiol Lung Cell Mol Physiol 291, L781-L793
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Transposon Mutagenesis Identifies Genes Associated with Mycoplasma pneumoniae Gliding Motility..
B. M. Hasselbring, C. A. Page, E. S. Sheppard, and D. C. Krause (2006)
J. Bacteriol. 188, 6335-6345
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Identification of a Spiroplasma citri hydrophilic protein associated with insect transmissibility..
N. Killiny, B. Batailler, X. Foissac, and C. Saillard (2006)
Microbiology 152, 1221-1230
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Mutant Analysis Reveals a Specific Requirement for Protein P30 in Mycoplasma pneumoniae Gliding Motility.
B. M. Hasselbring, J. L. Jordan, and D. C. Krause (2005)
J. Bacteriol. 187, 6281-6289
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Versatile Use of oriC Plasmids for Functional Genomics of Mycoplasma capricolum subsp. capricolum.
C. Janis, C. Lartigue, J. Frey, H. Wroblewski, F. Thiaucourt, A. Blanchard, and P. Sirand-Pugnet (2005)
Appl. Envir. Microbiol. 71, 2888-2893
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HMW1 Is Required for Stability and Localization of HMW2 to the Attachment Organelle of Mycoplasma pneumoniae.
M. J. Willby, M. F. Balish, S. M. Ross, K. K. Lee, J. L. Jordan, and D. C. Krause (2004)
J. Bacteriol. 186, 8221-8228
   Abstract »    Full Text »    PDF »
Microbial Stimulation by Mycoplasma fermentans Synergistically Amplifies IL-6 Release by Human Lung Fibroblasts in Response to Residual Oil Fly Ash (ROFA) and Nickel.
F. Gao, A. Barchowsky, A. A. Nemec, and J. P. Fabisiak (2004)
Toxicol. Sci. 81, 467-479
   Abstract »    Full Text »    PDF »
Disruption of a Gene Predicted To Encode a Solute Binding Protein of an ABC Transporter Reduces Transmission of Spiroplasma citri by the Leafhopper Circulifer haematoceps.
A. Boutareaud, J. L. Danet, M. Garnier, and C. Saillard (2004)
Appl. Envir. Microbiol. 70, 3960-3967
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The genus Spiroplasma and its non-helical descendants: phylogenetic classification, correlation with phenotype and roots of the Mycoplasma mycoides clade.
G. E. Gasparich, R. F. Whitcomb, D. Dodge, F. E. French, J. Glass, and D. L. Williamson (2004)
Int J Syst Evol Microbiol 54, 893-918
   Abstract »    Full Text »    PDF »
Effect of Polyclonal, Monoclonal, and Recombinant (Single-Chain Variable Fragment) Antibodies on In Vitro Morphology, Growth, and Metabolism of the Phytopathogenic Mollicute Spiroplasma citri.
S. Malembic, C. Saillard, J. M. Bove, and M. Garnier (2002)
Appl. Envir. Microbiol. 68, 2113-2119
   Abstract »    Full Text »    PDF »
Fructose operon mutants of Spiroplasma citri.
P. Gaurivaud, F. Laigret, E. Verdin, M. Garnier, and J. M. Bove (2000)
Microbiology 146, 2229-2236
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Phase Variations of the Mycoplasma penetrans Main Surface Lipoprotein Increase Antigenic Diversity.
O. Neyrolles, I. Chambaud, S. Ferris, M.-C. Prevost, T. Sasaki, L. Montagnier, and A. Blanchard (1999)
Infect. Immun. 67, 1569-1578
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Purification, Cloning, and Preliminary Characterization of a Spiroplasma citri Ribosomal Protein with DNA Binding Capacity.
L. Le Dantec, M. Castroviejo, J. M. Bove, and C. Saillard (1998)
J. Biol. Chem. 273, 24379-24386
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Detection of Mycoplasma hyopneumoniae in Bronchoalveolar Lavage Fluids of Pigs by PCR.
A. K. Baumeister, M. Runge, M. Ganter, A. A. Feenstra, F. Delbeck, and H. Kirchhoff (1998)
J. Clin. Microbiol. 36, 1984-1988
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Detection and confirmation of Mycoplasma pneumoniae in urogenital specimens by PCR [In Process Citation].
S Sharma, R Brousseau, and S Kasatiya (1998)
J. Clin. Microbiol. 36, 277-280
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A defined medium for a fastidious Spiroplasma.
K. Hackett, A. Ginsberg, S Rottem, R. Henegar, and R. Whitcomb (1987)
Science 237, 525-527
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Cultivation of the Drosophila Sex-Ratio Spiroplasma.
K. J. HACKETT, D. E. LYNN, D. L. WILLIAMSON, A. S. GINSBERG, and R. F. WHITCOMB (1986)
Science 232, 1253-1255
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Spiroplasmas: Diversity of Arthropod Reservoirs and Host-Parasite Relationships.
T. B. CLARK (1982)
Science 217, 57-59
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Mycoplasma pneumoniae infection: role of a surface protein in the attachment organelle.
P. Hu, R. Cole, Y. Huang, J. Graham, D. Gardner, A. Collier, and W. Clyde Jr (1982)
Science 216, 313-315
   Abstract »    PDF »
Helical mycoplasmas (spiroplasmas) from Ixodes ticks.
J. Tully, D. Rose, C. Yunker, J Cory, R. Whitcomb, and D. Williamson (1981)
Science 212, 1043-1045
   Abstract »    PDF »
Spiroplasmavirus citri 3: propagation, purification, proteins, and nucleic acid.
R. Cole, W. Mitchell, and C. Garon (1977)
Science 198, 1262-1263
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)