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Science 4 March 1977:
Vol. 195. no. 4281, pp. 878 - 880
DOI: 10.1126/science.402691
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Articles

Science, Vol 195, Issue 4281, 878-880
Copyright © 1977 by American Association for the Advancement of Science

articles

Lysis of human cultured lymphoblastoid cells by cell-induced activation of the properdin pathway

AN Theofilopoulos and LH Perrin

Human cultured lymphoblastoid cells incubated in normal human serum activate the properdin complement pathway without antibody. However, only cells bearing C3b immune adherence receptors bind components of the properdin complement pathway and undergo lysis. A similar surveillance mechanism may exist in man to limit growth of malignant B cells bearing C3b immune adherence receptors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Complement-Dependent Control of Teratoma Formation by Embryonic Stem Cells.
C. A. Koch, C. E. Jordan, and J. L. Platt (2006)
J. Immunol. 177, 4803-4809
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Science. ISSN 0036-8075 (print), 1095-9203 (online)