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Science 4 March 1977:
Vol. 195. no. 4281, pp. 875 - 877
DOI: 10.1126/science.841311
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Articles

Science, Vol 195, Issue 4281, 875-877
Copyright © 1977 by American Association for the Advancement of Science

articles

Effect of delta-9-tetrahydrocannabinol on uterine and vaginal cytology of ovariectomized rats

J Solomon, MA Cocchia, and R DiMartino

The estrogen-like activity of delta-9-tetrahydrocannabinol (delta9-THC), an active component of marihuana, as measured by uterine weight gain and vaginal smear techniques in ovariectomized rats, is reflected in histological examination of uterine and vaginal tissues. Doses of 1, 2.5, and 10 milligrams of delta9-THC per kilogram elicit hypertrophy and hyperplasia of the uterus; the dose of 2.5 milligrams per kilogram is most effective. There is an increase in stratification of vaginal epithelium with doses of 2.5 and 10 milligrams per kilogram; cornifying cells are seen with 2.5 milligrams per kilogram.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Gonadotropin-Releasing Hormone Secretion by Cannabinoids.
C. M. Gammon, G. M. Freeman Jr., W. Xie, S. L. Petersen, and W. C. Wetsel (2005)
Endocrinology 146, 4491-4499
   Abstract »    Full Text »    PDF »
Inhibition of gonadotropin by delta9-tetrahydrocannabinol:mediation by steroid receptors?.
R. Smith, N. Besch, P. Besch, and C. Smith (1979)
Science 204, 325-327
   Abstract »    PDF »
delta9-Tetrahydrocannabinol and 17beta-estradiol bind to different macromolecules in estrogen target tissues.
A. Okey and G. Bondy (1978)
Science 200, 312-314
   Abstract »    PDF »
Competition of delta 9-tetrahydrocannabinol with estrogen in rat uterine estrogen receptor binding.
A. Rawitch, G. Schultz, K. Ebner, and R. Vardaris (1977)
Science 197, 1189-1191
   Abstract »    PDF »


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