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Science 4 March 1977:
Vol. 195. no. 4281, pp. 873 - 875
DOI: 10.1126/science.841310
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Articles

Science, Vol 195, Issue 4281, 873-875
Copyright © 1977 by American Association for the Advancement of Science

articles

Avian muscular dystrophy: functional and biochemical improvement with diphenylhydantoin

RK Entrikin, KL Swanson, PM Weidoff, GT Patterson, and BW Wilson

Chicks affected with hereditary muscular dystrophy were injected twice daily with 20 milligrams of diphenylhydantoin per kilogram of body weight on days 1 to 40 after hatching. The righting ability of dystrophic chicks treated with diphenylhydantoin was improved compared to that of untreated dystrophic chicks, and acetylcholinesterase activity was reduced to normal levels in the posterior latissimus dorsi muscles.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Screening of Antiserotoninergic Drugs With the Genetically Dystrophic Chicken.
M. S. Hudecki, C. M. Pollina, A. K. Bhargava, and R. S. Hudecki (1980)
Arch Neurol 37, 545-550
   Abstract »    PDF »
Muscular dystrophy: inhibition of degeneration in vivo with protease inhibitors.
A Stracher, E. McGowan, and S. Shafiq (1978)
Science 200, 50-51
   Abstract »    PDF »


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