Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 March 1977:
Vol. 195. no. 4281, pp. 834 - 847
DOI: 10.1126/science.320661
Prev | Table of Contents | Next

Articles

Science, Vol 195, Issue 4281, 834-847
Copyright © 1977 by American Association for the Advancement of Science

articles

Control of influenza and poliomyelitis with killed virus vaccines

J Salk and D Salk

The requirements for inducing immunity against an infectious disease are outlined, and the application of these requirements to the development of effective vaccines (vaccinology) is discussed. Influenza and poliomyelitis are examined from this viewpoint, and data are presented that demonstrate the effectiveness of killed virus vaccines against these diseases. A comparison between live and killed poliovirus vaccines suggests the desirability of returning to the use of a killed virus vaccine for the eradication of polio. The natural history of influenza and experience with vaccination suggest that influenza might be brought under effective control by routine immunization in childhood with a polyvalent killed virus vaccine potentiated by an immunologic adjuvant.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cutting Edge: Antigen Presentation to CD8 T Cells after Influenza A Virus Infection.
E. Ingulli, C. Funatake, E. L. Jacovetty, and M. Zanetti (2009)
J. Immunol. 182, 29-33
   Abstract »    Full Text »    PDF »
Protection against Influenza A Virus by Memory CD8 T Cells Requires Reactivation by Bone Marrow-Derived Dendritic Cells.
P. Castiglioni, D. S. Hall, E. L. Jacovetty, E. Ingulli, and M. Zanetti (2008)
J. Immunol. 180, 4956-4964
   Abstract »    Full Text »    PDF »
Vaccine-Induced CD8+ Central Memory T Cells in Protection from Simian AIDS.
M. Vaccari, C. J. Trindade, D. Venzon, M. Zanetti, and G. Franchini (2005)
J. Immunol. 175, 3502-3507
   Abstract »    Full Text »    PDF »
Androstenediol-Induced Restoration of Responsiveness to Influenza Vaccination in Mice.
D. A. Padgett, R. C. MacCallum, R. M. Loria, and J. F. Sheridan (2000)
J. Gerontol. A Biol. Sci. Med. Sci. 55, 418B-424
   Abstract »    Full Text »
A formalin-inactivated whole SIV vaccine confers protection in macaques.
M Murphey-Corb, L. Martin, B Davison-Fairburn, R. Montelaro, M Miller, M West, S Ohkawa, G. Baskin, J. Zhang, S. Putney, et al. (1989)
Science 246, 1293-1297
   Abstract »    PDF »
Development and Evaluation of a Vaccine for Human Immunodeficiency Virus (HIV) Infection.
A. S. Fauci, R. C. Gallo, S. Koenig, J. Salk, and R. H. Purcell (1989)
Ann Intern Med 110, 373-385
   Abstract »    PDF »
Epidemiology of Acute Respiratory Illness During an Influenza Outbreak in a Nursing Home: A Prospective Study.
P. A. Gross, M. Rodstein, J. R. LaMontagne, R. A. Kaslow, A. J. Saah, S. Wallenstein, R. Neufeld, C. Denning, P. Gaerlan, and G. V. Quinnan (1988)
Arch Intern Med 148, 559-561
   Abstract »    PDF »
Inactivated Poliomyelitis Vaccination: Issues Reconsidered.
E. R. Alexander (1984)
JAMA 251, 2710-2712
   Abstract »    PDF »
The Virus of Poliomyelitis: From Discovery to Extinction.
J. Salk (1983)
JAMA 250, 808-810
   Abstract »    PDF »
Vaccine-Related Poliomyelitis.
H. Openshaw and J. S. Lieberman (1982)
Arch Intern Med 142, 1617
   Abstract »    PDF »
Poliomyelitis Prevention.
(1982)
Ann Intern Med 96, 630-634
   Abstract »    PDF »
Prevalence of Poliovirus Neutralizing Antibodies in Young Adult Women.
T. R. Mayer and H. H. Balfour (1981)
JAMA 246, 1207-1209
   Abstract »    PDF »
Commentary on Immunization.
E. B. SHAW (1980)
Arch Pediatr Adolesc Med 134, 130-132
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)