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Science 18 February 1977:
Vol. 195. no. 4279, pp. 693 - 694
DOI: 10.1126/science.190678
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Articles

Science, Vol 195, Issue 4279, 693-694
Copyright © 1977 by American Association for the Advancement of Science

articles

Regeneration of oligodendroglia during recovery from demyelinating disease

RM Herndon, DL Price, and LP Weiner

Infection of mice with the JHM strain of mouse hepatitis virus causes demyelination as a result of a cytolytic infection of oligodendroglia. In recovery, animals show remyelination, which could result either from surviving oligodendrocytes extending their territory or by generation of new oligodendroglia. Electron microscopic autoradiographic studies with 3H-labeled thymidine demonstrate that the cells associated with remyelination are newly generated oligodendroglia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Enhancement of central nervous system remyelination in immune and non-immune experimental models of demyelination.
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Experimental Neuropathology of Chronic Demyelination Induced by a JHM Virus Variant (DS).
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Arch Neurol 44, 839-842
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The Effect of Dexamethasone on L-{alpha}-Lysophosphatidyl Choline (Lysolecithin)-Induced Demyelination of the Rat Spinal Cord.
L. C. Triarhou and R. M. Herndon (1986)
Arch Neurol 43, 121-125
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Mature Oligodendrocytes: Division Following Experimental Demyelination in Adult Animals.
L. S. Arenella and R. M. Herndon (1984)
Arch Neurol 41, 1162-1165
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