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Science 18 February 1977:
Vol. 195. no. 4279, pp. 646 - 653
DOI: 10.1126/science.841304
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Articles

Science, Vol 195, Issue 4279, 646-653
Copyright © 1977 by American Association for the Advancement of Science

articles

Norepinephrine-dopamine interactions and behavior

SM Antelman and AR Caggiula

The proposed hypothesis is directed toward explaining a number of disparate findings in terms of a stress-related interaction between the NE- and DA-containing systems in the brain. The deleterious behavioral effects of decreased DA activity, for example, may be counterbalanced by a similar decrease occurring in NE activity, such compensation being most likely to occur under conditions of stress. This hypothesis may have application to the understanding of neurological and mental disorders such as Parkinson's disease and schizophrenia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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C. Drouin, L. Darracq, F. Trovero, G. Blanc, J. Glowinski, S. Cotecchia, and J.-P. Tassin (2002)
J. Neurosci. 22, 2873-2884
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Stress considered as an etiological factor in Alzheimer's disease.
A. D. Haggerty (1987)
American Journal of Alzheimer's Disease and Other Dementias 2, 12-16
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Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy.
D. van Kammen, L. Mann, D. Sternberg, M Scheinin, P. Ninan, Marder SR, W. van Kammen, R. Rieder, and M Linnoila (1983)
Science 220, 974-977
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Increased intracranial self-stimulation in rats after long-term administration of desipramine.
H. Fibiger and A. Phillips (1981)
Science 214, 683-685
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Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey.
T. Brozoski, R. Brown, H. Rosvold, and P. Goldman (1979)
Science 205, 929-932
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Norepinephrine in chronic paranoid schizophrenia: above-normal levels in limbic forebrain.
I. Farley, K. Price, E McCullough, J. Deck, W Hordynski, and O Hornykiewicz (1978)
Science 200, 456-458
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Science. ISSN 0036-8075 (print), 1095-9203 (online)