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Science 18 February 1977:
Vol. 195. no. 4279, pp. 646 - 653
DOI: 10.1126/science.841304
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Articles

Science, Vol 195, Issue 4279, 646-653
Copyright © 1977 by American Association for the Advancement of Science

articles

Norepinephrine-dopamine interactions and behavior

SM Antelman and AR Caggiula

The proposed hypothesis is directed toward explaining a number of disparate findings in terms of a stress-related interaction between the NE- and DA-containing systems in the brain. The deleterious behavioral effects of decreased DA activity, for example, may be counterbalanced by a similar decrease occurring in NE activity, such compensation being most likely to occur under conditions of stress. This hypothesis may have application to the understanding of neurological and mental disorders such as Parkinson's disease and schizophrenia.


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alpha 1b-Adrenergic Receptors Control Locomotor and Rewarding Effects of Psychostimulants and Opiates.
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Monoamine Neurotransmitter Interactions in Drug-Free and Neuroleptic-Treated Schizophrenics.
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Clinical and Biologic Response to Clozapine in Patients With Schizophrenia: Crossover Comparison With Fluphenazine.
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Arch Gen Psychiatry 49, 345-353
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Norepinephrine in Acute Exacerbations of Chronic Schizophrenia: Negative Symptoms Revisited.
D. P. van Kammen, J. Peters, J. Yao, W. B. van Kammen, T. Neylan, D. Shaw, and M. Linnoila (1990)
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Plasma 3-Methoxy-4-Hydroxyphenylglycol Changes Associated With Clinical State and Schizophrenic Subtype.
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Monoamine Neurotransmitter Interactions and the Prediction of Antidepressant Response.
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Arch Gen Psychiatry 44, 1078-1083
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Stress considered as an etiological factor in Alzheimer's disease.
A. D. Haggerty (1987)
American Journal of Alzheimer's Disease and Other Dementias 2, 12-16
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Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy.
D. van Kammen, L. Mann, D. Sternberg, M Scheinin, P. Ninan, Marder SR, W. van Kammen, R. Rieder, and M Linnoila (1983)
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Arch Gen Psychiatry 39, 735-742
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Increased intracranial self-stimulation in rats after long-term administration of desipramine.
H. Fibiger and A. Phillips (1981)
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Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey.
T. Brozoski, R. Brown, H. Rosvold, and P. Goldman (1979)
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CNS Changes in Hyperbilirubinemia: Functional Implications.
J. Y. Jew and D. Sandquist (1979)
Arch Neurol 36, 149-154
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Norepinephrine in chronic paranoid schizophrenia: above-normal levels in limbic forebrain.
I. Farley, K. Price, E McCullough, J. Deck, W Hordynski, and O Hornykiewicz (1978)
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