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Science 4 February 1977:
Vol. 195. no. 4277, pp. 499 - 501
DOI: 10.1126/science.402027
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Articles

Science, Vol 195, Issue 4277, 499-501
Copyright © 1977 by American Association for the Advancement of Science

articles

Primate model for long-term study of intraventricularly or intrathecally administered drugs and intracranial pressure

JH Wood, DG Poplack, WA Bleyer, and AK Ommaya

Meaningful pharmacokinetic investigations require animal systems which approximate the human situation. This report describes a primate model in which silicone catheters are placed into the fourth ventricle and the spinal subarachnoid space and connected to subcutaneous cerebrospinal fluid without tissue damage, prod, enables spinoventricular perfusion, and permits ventricular cerebrospinal fluid sampling over extended periods in unanethetized rhesus monkeys. This animal system may provide intraventricular pressure recordings and pharmacokinetic data similar to that obtained in man.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)