Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 February 1977:
Vol. 195. no. 4277, pp. 487 - 489
DOI: 10.1126/science.835006
Prev | Table of Contents | Next

Articles

Science, Vol 195, Issue 4277, 487-489
Copyright © 1977 by American Association for the Advancement of Science

articles

13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat

MB Sporn, RA Squire, CC Brown, JM Smith, ML Wenk, and S Springer

Transitional cell and squamous cell cancer of the bladder was induced in Wistar/Lewis female rats by direct instillation of N-methyl-N-nitrosourea into the bladder. Feeding of the synthetic retinoid, 13-cis-retinoid acid, inhibited the incidence and extent of bladder cancer in these rats, even when 13-cis-retinoic acid administration was begun after completion of the carcinogen treatment.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reduced Lecithin: Retinol Acyltransferase Expression Correlates with Increased Pathologic Tumor Stage in Bladder Cancer.
S. Boorjian, S. K. Tickoo, N. P. Mongan, H. Yu, D. Bok, R. R. Rando, D. M. Nanus, D. S. Scherr, and L. J. Gudas (2004)
Clin. Cancer Res. 10, 3429-3437
   Abstract »    Full Text »    PDF »
Chemoprevention of Cancer - Focusing on Clinical Trials.
T. Kakizoe (2003)
Jpn. J. Clin. Oncol. 33, 421-442
   Abstract »    Full Text »    PDF »
Effects of Novel Phenylretinamides on Cell Growth and Apoptosis in Bladder Cancer.
J. L. Clifford, A. L. Sabichi, C. Zou, X. Yang, V. E. Steele, G. J. Kelloff, R. Lotan, and S. M. Lippman (2001)
Cancer Epidemiol. Biomarkers Prev. 10, 391-395
   Abstract »    Full Text »
Basic Biological Sciences: Retinoic Acid Stimulates Degradation of Interstitial Collagen Fibrils by Rat Mucosal Keratinocytes in vitro.
B.R. Wells and H. Birkedal-Hansen (1985)
Journal of Dental Research 64, 1186-1190
   Abstract »    PDF »
Retinoids, Cancer, and the Skin.
P. M. Elias and M. L. Williams (1981)
Arch Dermatol 117, 160-180
   Abstract »    PDF »
Asbestos-induced epithelial changes in organ cultures of hamster trachea: inhibition by retinyl methyl ether.
B. Mossman, J. Craighead, and B. MacPherson (1980)
Science 207, 311-313
   Abstract »    PDF »
13-cis-Retinoic acid: inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.
C. Grubbs, R. Moon, R. Squire, G. Farrow, S. Stinson, D. Goodman, C. Brown, and M. Sporn (1977)
Science 198, 743-744
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)