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Science 4 February 1977:
Vol. 195. no. 4277, pp. 487 - 489
DOI: 10.1126/science.835006
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Articles

Science, Vol 195, Issue 4277, 487-489
Copyright © 1977 by American Association for the Advancement of Science

articles

13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat

MB Sporn, RA Squire, CC Brown, JM Smith, ML Wenk, and S Springer

Transitional cell and squamous cell cancer of the bladder was induced in Wistar/Lewis female rats by direct instillation of N-methyl-N-nitrosourea into the bladder. Feeding of the synthetic retinoid, 13-cis-retinoid acid, inhibited the incidence and extent of bladder cancer in these rats, even when 13-cis-retinoic acid administration was begun after completion of the carcinogen treatment.


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Basic Biological Sciences: Retinoic Acid Stimulates Degradation of Interstitial Collagen Fibrils by Rat Mucosal Keratinocytes in vitro.
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