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Science 21 January 1977:
Vol. 195. no. 4275, pp. 299 - 301
DOI: 10.1126/science.831277
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Articles

Science, Vol 195, Issue 4275, 299-301
Copyright © 1977 by American Association for the Advancement of Science

articles

Primary structure of cholera toxin beta-chain: a glycoprotein hormone analog?

A Kurosky, DE Markel, JW Peterson, and WM Fitch

The completed sequence of the beta-chain of cholera toxin (103 amino acid residues) was compared to the beta-chains of chorionic gonadotropin, thyrotropin, luteinizing, and follicle stimulating hormones. The overall chemical similarity of the toxin beta-chain to the hormones was not statistically different from random; however, a comparison of the first 40 residues of the toxin beta-chain to the glycoprotein hormones revealed a segment of the hormones which was significantly chemically similar. The probability was less than .003 that the similarity was due to chance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Similar amino acid sequences: chance or common ancestry?.
R. Doolittle (1981)
Science 214, 149-159
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Science. ISSN 0036-8075 (print), 1095-9203 (online)