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Science 14 January 1977:
Vol. 195. no. 4274, pp. 205 - 206
DOI: 10.1126/science.401544
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Articles

Science, Vol 195, Issue 4274, 205-206
Copyright © 1977 by American Association for the Advancement of Science

articles

Diabetic cataracts and flavonoids

SD Varma, A Mizuno, and JH Kinoshita

Oral administration of quercitrin, an inhibitor of aldose reductase, leads to a significant decrease in the accumulation of sorbitol in the lens of diabetic Octodon degus. The onset of cataract is effectively delayed when quercitrin is continuously administered. Thus in these diabetic animals, as in galactosemic rats, the use of an effective aldose reductase inhibitor impedes the course of cataract development. These observations support the hypothesis that in diabetes, as in galactosemia, aldose reductase plays a key role in initiating the formation of lens opacity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Responses of Human Lens Epithelial Cells to Quercetin and DMSO.
X.-G. Cao, X.-X. Li, Y.-Z. Bao, N.-Z. Xing, and Y. Chen (2007)
Invest. Ophthalmol. Vis. Sci. 48, 3714-3718
   Abstract »    Full Text »    PDF »
Role of Aldose Reductase and Oxidative Damage in Diabetes and the Consequent Potential for Therapeutic Options.
S. K. Srivastava, K. V. Ramana, and A. Bhatnagar (2005)
Endocr. Rev. 26, 380-392
   Abstract »    Full Text »    PDF »
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer.
E. Middleton Jr., C. Kandaswami, and T. C. Theoharides (2000)
Pharmacol. Rev. 52, 673-751
   Abstract »    Full Text »    PDF »
Polyol Pathway Metabolites in Human Cataracts: Correlation of Circulating Glycosylated Hemoglobin Content and Fasting Blood Glucose Levels.
B. C. Lerner, S. D. Varma, and R. D. Richards (1984)
Arch Ophthalmol 102, 917-920
   Abstract »    PDF »
Aldose Reductase in Diabetic Cataracts.
J. H. Kinoshita, P. Kador, and M. Catiles (1981)
JAMA 246, 257-261
   Abstract »    PDF »


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