Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 14 January 1977:
Vol. 195. no. 4274, pp. 193 - 195
DOI: 10.1126/science.831269
Prev | Table of Contents | Next

Articles

Science, Vol 195, Issue 4274, 193-195
Copyright © 1977 by American Association for the Advancement of Science

articles

Marek's disease: effects of B histocompatibility alloalleles in resistant and susceptible chicken lines

WE Briles, HA Stone, and RK Cole

Lines of chickens selected from a common ancestral population for either resistance or susceptibility to Marek's disease developed contrasting frequencies of particular B alloalleles. Comparison of inoculated sibs in backcross-families revealed that the B alloalleles characterizing the two lines accounted for an eightfold difference in tumor incidence. This genetic difference in tumorigenesis associated with the alloalleles of the major histocompatibility complex is probably expressed through the cell-mediated immune system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
MHC standing genetic variation and pathogen resistance in wild Atlantic salmon.
M. Dionne, K. M. Miller, J. J. Dodson, and L. Bernatchez (2009)
Phil Trans R Soc B 364, 1555-1565
   Abstract »    Full Text »    PDF »
Contribution of Mutation, Recombination, and Gene Conversion to Chicken Mhc-B Haplotype Diversity.
K. Hosomichi, M. M. Miller, R. M. Goto, Y. Wang, S. Suzuki, J. K. Kulski, M. Nishibori, H. Inoko, K. Hanzawa, and T. Shiina (2008)
J. Immunol. 181, 3393-3399
   Abstract »    Full Text »    PDF »
Associations between malaria and MHC genes in a migratory songbird.
H. Westerdahl, J. Waldenstrom, B. Hansson, D. Hasselquist, T. von Schantz, and S. Bensch (2005)
Proc R Soc B 272, 1511-1518
   Abstract »    Full Text »    PDF »
Comparative Genomic Analysis of Two Avian (Quail and Chicken) MHC Regions.
T. Shiina, S. Shimizu, K. Hosomichi, S. Kohara, S. Watanabe, K. Hanzawa, S. Beck, J. K. Kulski, and H. Inoko (2004)
J. Immunol. 172, 6751-6763
   Abstract »    Full Text »    PDF »
Differential Cytokine Responses following Marek's Disease Virus Infection of Chickens Differing in Resistance to Marek's Disease.
P. Kaiser, G. Underwood, and F. Davison (2002)
J. Virol. 77, 762-768
   Abstract »    Full Text »    PDF »
Identification of the Neoplastically Transformed Cells in Marek's Disease Herpesvirus-Induced Lymphomas: Recognition by the Monoclonal Antibody AV37.
S. C. Burgess and T. F. Davison (2002)
J. Virol. 76, 7276-7292
   Abstract »    Full Text »    PDF »
Major Histocompatibility Complex Variation in the Endangered Przewalski's Horse.
P. W. Hedrick, K. M. Parker, E. L. Miller, and P. S. Miller (1999)
Genetics 152, 1701-1710
   Abstract »    Full Text »
Summary: The New Pragmatics of Immunology.
J.C. Howard (1989)
Cold Spring Harb Symp Quant Biol 54, 947-957
   Abstract »    PDF »
Resistance to a malignant lymphoma in chickens is mapped to subregion of major histocompatibility (B) complex.
W. Briles, R. Briles, R. Taffs, and H. Stone (1983)
Science 219, 977-979
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)