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Science 14 January 1977:
Vol. 195. no. 4274, pp. 177 - 179
DOI: 10.1126/science.401543
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Articles

Science, Vol 195, Issue 4274, 177-179
Copyright © 1977 by American Association for the Advancement of Science

articles

Insulin, glucagon, and glucose exhibit synchronous, sustained oscillations in fasting monkeys

CJ Goodner, BC Walike, DJ Koerker, JW Ensinck, AC Brown, EW Chideckel, J Palmer, and L Kalnasy

In overnight fasted rhesus monkeys, synchronous, regular oscillations occurred in the plasma concentrations of glucose, insulin, and glucagon. The oscillations displayed a period averaging 9 minutes. The amplitudes for insulin and glucagon were ten and five times greater than for glucose. Insulin cycled in and glucagon out of phase with glucose. In baboons, oscillations of glucose and insulin were smaller than in rhesus monkeys, while in man, regular oscillations were not observed.


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