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Science 7 January 1977:
Vol. 195. no. 4273, pp. 76 - 78
DOI: 10.1126/science.318761
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Articles

Science, Vol 195, Issue 4273, 76-78
Copyright © 1977 by American Association for the Advancement of Science

articles

Tris(2,3-dibromopropyl) phosphate: mutagenicity of a widely used flame retardant

MJ Prival, EC McCoy, B Gutter, and HS Rosendranz

Tris(2,3-dibromopropyl) phosphate, a widely used flame-retardant additive for textiles, is mutagenic to histidine-requiring strains of Salmonella typhimurium. Extracts of fabrics treated with this compound are also capable of inducing mutations in these bacterial strains.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chronic Toxicity and Carcinogenic Potential of Tris-(1,3-Dichloro-2-propyl) Phosphate in Sprague-Dawley Rat.
R. I. Freudenthal and R. T. Henrich (2000)
International Journal of Toxicology 19, 119-125
   Abstract »    PDF »
Metabolism and Genotoxicity of the Halogenated Alkyl Compound Tris(2,3-Dibromopropyl)phosphate.
G.J.M. van Beerendonk, S.D. Nelson, and J.H.N. Meerman (1994)
Human and Experimental Toxicology 13, 861-865
   Abstract »    PDF »
Tris(dichloropropyl)phosphate, a mutagenic flame retardant: frequent cocurrence in human seminal plasma.
T Hudec, J Thean, D Kuehl, and R. Dougherty (1981)
Science 211, 951-952
   Abstract »    PDF »
Identifying environmental chemicals causing mutations and cancer.
B. Ames (1979)
Science 204, 587-593
   Abstract »    PDF »
Children absorb tris-BP flame retardant from sleepwear: urine contains the mutagenic metabolite, 2,3-dibromopropanol.
A Blum, M. Gold, B. Ames, F. Jones, E. Hett, R. Dougherty, E. Horning, I Dzidic, D. Carroll, R. Stillwell, et al. (1978)
Science 201, 1020-1023
   Abstract »    PDF »
Permanence of Flame Retardance in Flexible Polyurethane Foams.
R. L. McBrayer (1978)
Journal of Cellular Plastics 14, 224-233
Another flame retardant, tris-(1,3-dichloro-2-propyl)-phosphate, and its expected metabolites are mutagens.
M. Gold, A Blum, and B. Ames (1978)
Science 200, 785-787
   Abstract »    PDF »
Flame-retardant additives as possible cancer hazards.
A Blum and B. Ames (1977)
Science 195, 17-23
   PDF »


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