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Science 7 January 1977:
Vol. 195. no. 4273, pp. 74 - 75
DOI: 10.1126/science.831257
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Articles

Science, Vol 195, Issue 4273, 74-75
Copyright © 1977 by American Association for the Advancement of Science

articles

Thymic muscle cells bear acetylcholine receptors: possible relation to myasthenia gravis

I Kao and DB Drachman

Culture of dissociated thymus from rats and humans yielded cells identical to skeletal muscle with respect to morphology, contractility, electrophysiological properties, and the presence of acetylcholine receptors. These cells, strategically located in the thymus, may play a role in initiation of the autoimmune response against acetylcholine receptors, which is characteristic of myasthenia gravis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Establishment of a Human Thymic Myoid Cell Line : Phenotypic and Functional Characteristics.
A. Wakkach, S. Poea, E. Chastre, C. Gespach, F. Lecerf, S. De la Porte, S. Tzartos, A. Coulombe, and S. Berrih-Aknin (1999)
Am. J. Pathol. 155, 1229-1240
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Mild Clinical Expression of Myasthenia Gravis Associated with Autoimmune Thyroid Diseases.
M. Marino, R. Ricciardi, A. Pinchera, G. Barbesino, L. Manetti, L. Chiovato, L. E. Braverman, B. Rossi, A. Muratorio, and S. Mariotti (1997)
J. Clin. Endocrinol. Metab. 82, 438-443
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Assembly of Human Neuronal Nicotinic Receptor alpha 5 Subunits with alpha 3, beta 2, and beta 4 Subunits.
F. Wang, V. Gerzanich, G. B. Wells, R. Anand, X. Peng, K. Keyser, and J. Lindstrom (1996)
J. Biol. Chem. 271, 17656-17665
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Myasthenia Gravis.
D. B. Drachman (1994)
N. Engl. J. Med. 330, 1797-1810
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The neuroendocrine thymus: coexistence of oxytocin and neurophysin in the human thymus.
V Geenen, J. Legros, P Franchimont, M Baudrihaye, M. Defresne, and J Boniver (1986)
Science 232, 508-511
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Binding of Iodine 125 {alpha}-Bungarotoxin to the Thymus of Mice.
F. Ohshima, K. Kondo, and T. Tsubaki (1978)
Arch Neurol 35, 31-32
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