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Science 7 January 1977:
Vol. 195. no. 4273, pp. 64 - 66
DOI: 10.1126/science.831255
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Articles

Science, Vol 195, Issue 4273, 64-66
Copyright © 1977 by American Association for the Advancement of Science

articles

Subacute sclerosing panencephalitis: experimental infection in primates

P Albrecht, T Burnstein, MJ Klutch, HT Hicks, and FA Ennis

Measles virus isolated from the brain of a 12-year-old boy with subacute sclerosing panencephalitis caused a chronic, progressive encephalitis in experimentally infected rhesus monkeys. The infection was eventually fatal in spite of pre-existing measles immunity and a vigorous secondary antibody response in serum and cerebrospinal fluid of the infected animals. The findings provide a basis for studies into the pathogenesis and possible treatment of the human disease.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)