Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 December 1976:
Vol. 194. no. 4272, pp. 1434 - 1436
DOI: 10.1126/science.1006310
Prev | Table of Contents | Next

Articles

Science, Vol 194, Issue 4272, 1434-1436
Copyright © 1976 by American Association for the Advancement of Science

articles

Infidelity of DNA synthesis in vitro: screening for potential metal mutagens or carcinogens

MA Sirover and LA Loeb

Thirty-one metal salts have been tested for their ability to affect the accuracy of DNA synthesis in vitro. All ten salts of metal carcinogens decreased the fidelity of DNA synthesis. Of the three metals which beforehand were considered to be possible mutagens or carcinogens, only one decreased fidelity. In contrast, 17 noncarcinogenic metal salts did not affect fidelity even when present at concentrations that were clearly inhibitory.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DNA Polymerase {beta} Substrate Specificity: SIDE CHAIN MODULATION OF THE "A-RULE".
W. A. Beard, D. D. Shock, V. K. Batra, L. C. Pedersen, and S. H. Wilson (2009)
J. Biol. Chem. 284, 31680-31689
   Abstract »    Full Text »    PDF »
Lesion Bypass of N2-Ethylguanine by Human DNA Polymerase {iota}.
M. G. Pence, P. Blans, C. N. Zink, T. Hollis, J. C. Fishbein, and F. W. Perrino (2009)
J. Biol. Chem. 284, 1732-1740
   Abstract »    Full Text »    PDF »
Lesion Bypass Activity of DNA Polymerase A from the Extremely Radioresistant Organism Deinococcus radiodurans.
K. Heinz and A. Marx (2007)
J. Biol. Chem. 282, 10908-10914
   Abstract »    Full Text »    PDF »
Biochemical and Kinetic Characterization of the DNA Helicase and Exonuclease Activities of Werner Syndrome Protein.
S. Choudhary, J. A. Sommers, and R. M. Brosh Jr. (2004)
J. Biol. Chem. 279, 34603-34613
   Abstract »    Full Text »    PDF »
Effect of manganese on in vitro replication of damaged DNA catalyzed by the herpes simplex virus type-1 DNA polymerase.
G. Villani, N. Tanguy Le Gac, L. Wasungu, D. Burnouf, R. P. Fuchs, and P. E. Boehmer (2002)
Nucleic Acids Res. 30, 3323-3332
   Abstract »    Full Text »    PDF »
Correlations of Blood Lead with DNA-Protein Cross-Links and Sister Chromatid Exchanges in Lead Workers.
F.-Y. Wu, P.-W. Chang, C.-C. Wu, and H.-W. Kuo (2002)
Cancer Epidemiol. Biomarkers Prev. 11, 287-290
   Abstract »    Full Text »    PDF »
Cadmium mutagenicity and human nucleotide excision repair protein XPA: CD, EXAFS and 1H/15N-NMR spectroscopic studies on the zinc(II)- and cadmium(II)-associated minimal DNA-binding domain (M98-F219).
G. W. Buchko, N. J. Hess, and M. A. Kennedy (2000)
Carcinogenesis 21, 1051-1057
   Abstract »    Full Text »    PDF »
Cobaltous chloride-induced mutagenesis in the supF tRNA gene of Escherichia coli.
H.I. Ogawa, Y. Ohyama, Y. Ohsumi, K. Kakimoto, Y. Kato, Y. Shirai, T. Nunoshibaand, and K. Yamamoto (1999)
Mutagenesis 14, 249-253
   Abstract »    Full Text »    PDF »
Yes, But Is It a Human Carcinogen?.
A. Furst (1990)
International Journal of Toxicology 9, 1-18
   PDF »
A Survey of Metal-induced Mutagenicity in Vitro and in Vivo.
K. Hansen and R. M. Stern (1984)
International Journal of Toxicology 3, 381-430
   Abstract »    PDF »
The Relationship Between Prenatal Exposure to Lead and Congenital Anomalies.
H. L. Needleman, M. Rabinowitz, A. Leviton, S. Linn, and S. Schoenbaum (1984)
JAMA 251, 2956-2959
   Abstract »    PDF »
Carcinogen testing: current problems and new approaches.
J. Weisburger and G. Williams (1981)
Science 214, 401-407
   Abstract »    PDF »
On the Fidelity of DNA Replication.
L. A. Loeb, L. A. Weymouth, T. A. Kunkel, K. P. Gopinathan, R. A. Beckman, and D. K. Dube (1979)
Cold Spring Harb Symp Quant Biol 43, 921-927
   Abstract »    PDF »
Mutagenicity of filtrates from respirable coal fly ash..
C. E. CHRISP, G. L. FISHER, and J. E. LAMMERT (1978)
Science 199, 73-75
   Abstract »    PDF »
Metal mutagens and carcinogens affect RNA synthesis rates in a distinct manner.
D. Hoffman and S. Niyogi (1977)
Science 198, 513-514
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)