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Science 24 December 1976:
Vol. 194. no. 4272, pp. 1434 - 1436
DOI: 10.1126/science.1006310
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Articles
Science, Vol 194, Issue 4272, 1434-1436
Copyright © 1976 by American Association for the Advancement of Science
Infidelity of DNA synthesis in vitro: screening for potential metal mutagens or carcinogens
MA Sirover
and
LA Loeb
Thirty-one metal salts have been tested for their ability to affect the accuracy of DNA synthesis in vitro. All ten salts of metal carcinogens decreased the fidelity of DNA synthesis. Of the three metals which beforehand were considered to be possible mutagens or carcinogens, only one decreased fidelity. In contrast, 17 noncarcinogenic metal salts did not affect fidelity even when present at concentrations that were clearly inhibitory.
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