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Science 24 December 1976:
Vol. 194. no. 4272, pp. 1421 - 1423
DOI: 10.1126/science.795030
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Articles

Science, Vol 194, Issue 4272, 1421-1423
Copyright © 1976 by American Association for the Advancement of Science

articles

Calcium and secretion: distinction between two pools of glucose-sensitive calcium in pancreatic islets

B Hellman, J Sehlin, and IB Taljedal

D-Glucose, but not L-glucose or 3-O-methyl-D-glucose, stimulates 45Ca2+ uptake by both lanthanum-displaceable and lanthanum-nondisplaceable pools in pancreatic islets. The nondisplaceable pool probably represents secretory granules, while the displaceable pool may be located in the beta-cell membrane. Kinetic studies with isotopically labeled islets suggest that only the displaceable pool participates in the short-term coupling of the glucose stimulus with secretion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dense core secretory vesicles revealed as a dynamic Ca2+ store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera.
K. J. Mitchell, P. Pinton, A. Varadi, C. Tacchetti, E. K. Ainscow, T. Pozzan, R. Rizzuto, and G. A. Rutter (2001)
J. Cell Biol. 155, 41-52
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Science. ISSN 0036-8075 (print), 1095-9203 (online)