Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 10 December 1976:
Vol. 194. no. 4270, pp. 1181 - 1182
DOI: 10.1126/science.1033604
Prev | Table of Contents | Next

Articles

Science, Vol 194, Issue 4270, 1181-1182
Copyright © 1976 by American Association for the Advancement of Science

articles

Suppression by 1,3-butanediol of the ethanol withdrawal syndrome in rats

E Majchrowicz, WA Hunt, and C Piantadosi

1,3-Butanediol was tested for its ability to suppress an ethanol with drawal syndrome. Male Sprague-Dawley rats were rendered physically dependent on ethanol by intragastric administration of ethanol at a dosage of 9 to 15 grams per kilogram per day over a 4-day period. A nonintoxicating oral dose of 1,3-butanediol at 4 grams per kilogram administered after elimination of ethanol from the blood was effective against the tremulous and conbulsive components of the ethanol withdrawal syndrome in all animals for 1 to 5 hours. This period coincided with the time of maximum severity of the withdrawal syndrome, as seen in the control animals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Birthweight Depression in Male Rats Contiguous to Male Siblings in Utero Exposed to High Doses of 1,3-Butanediol during Organogenesis.
R. F. Mankes, V. Renak, J. Fieseher, and R. Lefevre (1986)
International Journal of Toxicology 5, 189-196
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)