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Science 3 December 1976:
Vol. 194. no. 4269, pp. 1079 - 1081
DOI: 10.1126/science.982064
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Articles

Science, Vol 194, Issue 4269, 1079-1081
Copyright © 1976 by American Association for the Advancement of Science

articles

Time-dependent disruption of morphine tolerance by electroconvulsive shock and frontal cortical stimulation

RP Kesner, DJ Priano, and DeWitt JR

Electroconvulsive shock or frontal cortex stimulation administered to rats at 5 but not at 180 minutes after an initial administration of morphine sulfate disrupted the development of one-trial tolerance to the analgesic effects of morphine sulfate. It is suggested that development of tolerance may be mediated by cellular mechanisms and memory processes similar to those thought to underlie conventional learning.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Morphine Tolerance: Is There Evidence for a Conditioning Model?.
S. SIEGEL (1978)
Science 200, 344-345
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