Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 3 December 1976:
Vol. 194. no. 4269, pp. 1069 - 1071
DOI: 10.1126/science.982062
Prev | Table of Contents | Next

Articles

Science, Vol 194, Issue 4269, 1069-1071
Copyright © 1976 by American Association for the Advancement of Science

articles

25-hydroxyvitamin D: autoradiographic evidence of sites of action in epiphyseal cartilage and bone

FH Wezeman

Tritiated 25-hydroxyvitamin D3 was administered to growing rats to morphologically documents its sites of action. Highly selective incorporation occurred in epiphyseal hypertrophic cells, epiphyseal matrix, osteoid, osteoblasts, and osteocytes of metaphyseal bone spicules. The labeled metabolite appeared in chondrocytic lacunar matrix coincident with hypertrophic cell death as evidenced by histological examination. The tritiated 25-hydroxyvitamin D3 became localized only in areas of active mineralization.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid.
W. Stumpf, M Sar, F. Reid, Y Tanaka, and H. DeLuca (1979)
Science 206, 1188-1190
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)