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Science 3 December 1976:
Vol. 194. no. 4269, pp. 1062 - 1064
DOI: 10.1126/science.988637
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Articles

Science, Vol 194, Issue 4269, 1062-1064
Copyright © 1976 by American Association for the Advancement of Science

articles

Hydroxymethyluracil in eukaryote DNA: a natural feature of the pyrrophyta (dinoflagellates)

PM Rae

Analysis of the DNA of several diverse dinoflagellates and other algae has revealed that the presence of the base hydroxymethyluracil (HOMeU) is a feature common among the DNA's of dinoflagellates; this base has not been found in any other group of eukaryotes that has been examined. Among examined members of the dinoflagellates, the ratio of the base pairs HOMeU-A to T-A, where A is adenine and T is thymine, ranges from 0.14 to 2.13. In addition to hydroxymethyluracil, the DNA of one dinoflagellate contains methylcytosine, and that of another contains methyladenine, while the DNA of other dinoflagellates contains no detectable amounts of either of these two bases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dinoflagellates: a remarkable evolutionary experiment.
J. D. Hackett, D. M. Anderson, D. L. Erdner, and D. Bhattacharya (2004)
Am. J. Botany 91, 1523-1534
   Abstract »    Full Text »    PDF »
Biosynthesis and Function of the Modified DNA Base beta -D-Glucosyl-Hydroxymethyluracil in Trypanosoma brucei.
F. van Leeuwen, R. Kieft, M. Cross, and P. Borst (1998)
Mol. Cell. Biol. 18, 5643-5651
   Abstract »    Full Text »    PDF »
beta -D-Glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres.
F. van Leeuwen, M. C. Taylor, A. Mondragon, H. Moreau, W. Gibson, R. Kieft, and P. Borst (1998)
PNAS 95, 2366-2371
   Abstract »    Full Text »    PDF »


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