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Science 3 December 1976:
Vol. 194. no. 4269, pp. 1060 - 1061
DOI: 10.1126/science.10629
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Articles

Science, Vol 194, Issue 4269, 1060-1061
Copyright © 1976 by American Association for the Advancement of Science

articles

Choline administration: activation of tyrosine hydroxylase in dopaminergic neurons of rat brain

IH Ulus and RJ Wurtman

The administration of choline in doses previously shown to elevate brain acetylcholine concentrations also increases the activity of tyrosine hydroxylase in rat caudate nuclei. This response can be blocked by atropine, a muscarinic antagonist. These findings indicate that choline-induced increases in acetylcholine concentrations may be associated with parallel changes in the amount of the neurotransmitter released into synapses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Decreased Brain Choline Uptake in Older Adults: An In Vivo Proton Magnetic Resonance Spectroscopy Study.
B. M. Cohen, P. F. Renshaw, A. L. Stoll, R. J. Wurtman, D. Yurgelun-Todd, and S. M. Babb (1995)
JAMA 274, 902-907
   Abstract »    PDF »
Choline and cholinergic neurons.
J. Blusztajn and R. Wurtman (1983)
Science 221, 614-620
   Abstract »    PDF »
Age-related changes in passive avoidance retention: modulation with dietary choline.
R. Bartus, R. Dean, J. Goas, and A. Lippa (1980)
Science 209, 301-303
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Cholinomimetics and Memory: The Effect of Choline Chloride.
K. L. Davis, R. C. Mohs, J. R. Tinklenberg, L. E. Hollister, A. Pfefferbaum, and B. S. Kopell (1980)
Arch Neurol 37, 49-52
   Abstract »    PDF »
Choline excites cortical neurons.
K Krnjevic and W Reinhardt (1979)
Science 206, 1321-1323
   Abstract »    PDF »
Lecithin consumption increases acetylcholine concentrations in rat brain and adrenal gland.
M. Hirsch and R. Wurtman (1978)
Science 202, 223-225
   Abstract »    PDF »
Chronic, Multiple Tics of Gilles de la Tourette's Disease: CSF Acid Monoamine Metabolites After Probenecid Administration.
D. J. Cohen, B. A. Shaywitz, B. Caparulo, J. G. Young, and M. B. Bowers Jr (1978)
Arch Gen Psychiatry 35, 245-250
   Abstract »    PDF »


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