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Science 26 November 1976:
Vol. 194. no. 4268, pp. 967 - 968
DOI: 10.1126/science.982058
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Articles

Science, Vol 194, Issue 4268, 967-968
Copyright © 1976 by American Association for the Advancement of Science

articles

Nitrous oxide "analgesia": resemblance to opiate action

BA Berkowitz, SH Ngai, and AD Finck

Nitrous oxide produced a dose-related "analgesia" in mice (median effective dose, 55 percent). The analgesia was evaluated by means of a phenylquinone writhing test. Narcotic antagonists or chronic morphinization reduced nitrous oxide analgesia. Either nitrous oxide releases an endogenous analgesic or narcotic antagonists have analgesic antagonist properties heretofore unappreciated.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Self-administered nitrous oxide for the management of incident pain in terminally ill patients: a blinded case series.
J. L Parlow, B. Milne, D. A Tod, G I. Stewart, J. M Griffiths, and D. J Dudgeon (2005)
Palliative Medicine 19, 3-8
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Role of Nitric-Oxide Synthase Isoforms in Nitrous Oxide Antinociception in Mice.
M. Ishikawa and R. M. Quock (2003)
J. Pharmacol. Exp. Ther. 306, 484-489
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Staircase Assessment of the Magnitude and Time-course of 50% Nitrous-oxide Analgesia.
E. Kaufman, D.C. Chastain, A.M. Gaughan, and R.H. Gracely (1992)
Journal of Dental Research 71, 1598-1603
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Subacute Toxic Delirium Caused by Nitrous Oxide May Be an Acute Withdrawal State.
M. A. Gillman, F. J. Lichtigfeld, and R. Sandyk (1984)
Arch Neurol 41, 704
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Plasma Beta-Endorphin-like Immunoreactivity, Pain and Anxiety Following Administration of Placebo in Oral Surgery Patients.
K.M. Hargreaves, R.A. Dionne, and G.P. Mueller (1983)
Journal of Dental Research 62, 1170-1173
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